Synlett 2011(12): 1784-1785  
DOI: 10.1055/s-0030-1260936
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Raghunath Chowdhury*
Bio-Organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India
e-Mail: raghuch14@gmail.com;
Further Information

Publication History

Publication Date:
05 July 2011 (online)

Introduction

Last decade witnessed an explosive growth in asymmetric organocatalysis. A large number of organocatalysts have been developed by different research groups. (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine (CAS: 51207-66-0) is a versatile organocatalyst, which is commercially available or can be easily prepared from commercially available Cbz-(l)-proline (Scheme  [¹] ). [¹] It is known to catalyze many organic reactions, for example, the asymmetric ­aldol reaction, [²] [³] Michael reaction, [4-7] Mannich reaction, [8] and the domino reaction. [9] It is also used as a chiral ligand/additive in metal-mediated stereoselective organic syntheses. [¹0] [¹¹]

Scheme 1

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