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Synfacts 2011(8): 0862-0862  
DOI: 10.1055/s-0030-1260744
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Aza-Darzens Reaction Catalyzed by Mg Phosphate Salt

Contributor(s): Hisashi Yamamoto, Jiajing Tan
S. E. Larson, G. L. Li, G. B. Rowland, D. Junge, R. C. Huang, H. L. Woodcock, J. C. Antilla*
University of South Florida, Tampa, Mississippi State University, USA and Sun Yat-Sen University, Guangzhou, P. R. of China
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Publikationsdatum:
20. Juli 2011 (online)

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Significance

Chiral magnesium-VAPOL phosphate salt was successfully employed as a catalyst for the asymmetric aza-Darzens reaction through the addition of α-chloro-1,3-dicarbonyl compounds. The corresponding aziridines are ­obtained with good yields and enantioselectivities.