Synlett 2011(10): 1479-1480  
DOI: 10.1055/s-0030-1260575
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

Isatoic Anhydride

Sudipta Raha Roy*
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160062, India
e-Mail: sudiptaraharoy@gmail.com;
Further Information

Publication History

Publication Date:
26 May 2011 (online)

Introduction

The abundance of heterocyclic motifs in bio-active natural products challenges many researchers to acquire such heterocyclic compounds in the laboratory level. The progress of green chemistry in the synthetic process favors the tandem reactions over the multistep synthesis. Isatoic anhydride (1) is a fascinating molecule with a broad spectrum in the synthesis of pharmaceuticals and natural products by tandem reactions. It is commercially available and can be synthesized by different approaches (Scheme  [¹] ). [¹]

Scheme 1  Synthesis of isatoic anhydride (1)

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