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Synfacts 2011(7): 0766-0766
DOI: 10.1055/s-0030-1260505
DOI: 10.1055/s-0030-1260505
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd-Catalyzed Synthesis of Isoindolines via Cascade Reaction
F. J. Williams, E. R. Jarvo*
University of California, Irvine, USA
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
In this report, a novel palladium-catalyzed cascade reaction affording cis-1,3-disubstituted isoindolines is described. After an initial arylation of the imine starting material, the resultant sulfonamide engages the allylic acetate by an aminopalladation reaction, which after β-acetoxy elimination affords the desired heterocyclic products.