Synthesis 2011(12): 1847-1852  
DOI: 10.1055/s-0030-1260463
© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Conjugate Additions of Acetylacetone to 3-Ylideneoxindoles: A Direct Access to Highly Enantioenriched Oxindole Derivatives

Shu-Wen Duan, Hai-Hua Lu, Fu-Gen Zhang, Jun Xuan, Jia-Rong Chen, Wen-Jing Xiao*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, P. R. of China
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Publication History

Received 15 March 2011
Publication Date:
13 May 2011 (eFirst)


A highly enantioselective organocatalytic conjugate addition of acetylacetone to 3-ylideneoxindoles is described. This method provides polysubstituted oxindoles in good to excellent enantioselectivities and high isolated yields.