Pyrroles and Indolizidines from Deprotonated α-(Alkylideneamino)nitriles
29 April 2011 (eFirst)
Their ready availability from simple starting materials in only two synthetic steps and their versatility as building blocks for the construction of highly substituted amines and N-heterocycles renders α-(alkylideneamino)nitriles useful synthetic intermediates. Herein, short syntheses of tri- and tetrasubstituted pyrroles including the northern half of the HMG-CoA reductase inhibitor atorvastatin as well as an access to 3-substituted indolizidines will be described.
heterocycles - carbanions - pyrroles - Umpolung - Michael addition