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Synthesis 2011(19): 3185-3189  
DOI: 10.1055/s-0030-1260170
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a New Class of Phosphinic Acids: Synthesis of Novel Four-Membered Cyclic Oxaphosphetanes by Intramolecular Mitsunobu Reaction of Bis(α-hydroxyalkyl)phosphinic Acids

Babak Kaboudin*a, Hamideh Haghighata, Tsutomu Yokomatsub
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran
Fax: +98(241)4214949; e-Mail: kaboudin@iasbs.ac.ir;
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horonouchi, Hachioji, Tokyo 192-0392, Japan
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Publikationsverlauf

Received 20 June 2011
Publikationsdatum:
12. August 2011 (online)

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Abstract

A novel class of phosphinic acid derivatives, four-membered cyclic oxaphosphetanes, was synthesized by the reaction of bis(hydroxymethyl)phosphinic acids with a mixture of triphenylphosphine and diisopropyl azodicarboxylate in toluene-dichloromethane at room temperature via an intramolecular Mitsunobu reaction.

Key words

bis(α-hydroxyalkyl)phosphinic acids - oxaphosphetane - cyclic phosphinic acids - Mitsunobu reaction

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