Synthesis 2011(18): 2893-2896  
DOI: 10.1055/s-0030-1260167
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Reliable and Safe, Gram-Scale Hydrogenation and Hydrogenolysis of O-Benzyl Ether Groups with In Situ Pd0/C Catalyst

François-Xavier Felpin*a,b,, Eric Fouqueta
a Université de Bordeaux, CNRS-UMR 5255, Institut des Sciences Moléculaires, 351 cours de la Libération, 33405 Talence, France
b Université de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France
Fax: +33(5)40006286; e-Mail: [email protected];
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Publikationsverlauf

Received 1 July 2011
Publikationsdatum:
10. August 2011 (online)

Abstract

Hydrogenation of alkenes, alkynes, and hydrogenolysis of O-benzyl ethers with Pd0/C catalyst generated in situ can be readily scaled up under safer conditions than with traditional procedures. The precise control of the palladium loading and the mild conditions developed allow the formation of a very active and reliable Pd0/C catalyst, leading to highly reproducible results.

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Present address: Université de Nantes.

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Activated Carbon, Darco® G-60, 100 mesh, was used in this study. However, we did not observe dramatic differences with other types of charcoal.