Synthesis 2011(16): 2644-2650  
DOI: 10.1055/s-0030-1260099
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Facile Synthesis of Pyrimidine-Isoxazoline Hybrids in a [bmim][PF6]-Water Biphasic System

Kushal Lanjewara, Anjali Rahatgaonkar*a, Mukund Chorghadeb, Binda Sarafa
a Chemistry Department, Institute of Science, Civil Lines, Nagpur 440001, MS, India
e-Mail: anjali_rahatgaonkar@yahoo.com;
b Chorghade Enterprises, 14 Carlson Circle, Natick, MA 01760-4205, USA
Further Information

Publication History

Received 25 March 2011
Publication Date:
27 July 2011 (online)

Abstract

The convenient synthesis of a library of pyrimidine-isoxazoline hybrids in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6])-water/potassium hydroxide at ambient temperature has been accomplished. The ionic liquid [bmim][PF6], immiscible in water, can be easily recycled for reuse after separation of the products without any noticeable diminution in its activity. The protocol is rapid, the yields are good to excellent, and the method is facile.

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