Synthesis 2011(9): 1383-1398  
DOI: 10.1055/s-0030-1259981
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization

Jonathan Sperry, Yen-Cheng (William) Liu, Zoe E. Wilson, Jonathan G. Hubert, Margaret A. Brimble*
Department of Chemistry, University of Auckland, 23 Symonds St., Auckland 1142, New Zealand
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Further Information

Publication History

Received 20 January 2011
Publication Date:
04 April 2011 (eFirst)


The synthesis of both mono and bisbenzannulated spiroketals using an oxidative radical cyclization approach is investigated. Although unsuccessful in uncovering a novel route toward bisbenzannulated spiroketals, the oxidative radical cyclization does facilitate a new approach to monobenzannulated spiroketals such as those found in berkelic acid and in the chaetoquadrins.