Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization
04 April 2011 (eFirst)
The synthesis of both mono and bisbenzannulated spiroketals using an oxidative radical cyclization approach is investigated. Although unsuccessful in uncovering a novel route toward bisbenzannulated spiroketals, the oxidative radical cyclization does facilitate a new approach to monobenzannulated spiroketals such as those found in berkelic acid and in the chaetoquadrins.
spiroketals - berkelic acid - chaetoquadrin - radical cyclization - cross-metathesis