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Synthesis 2011(9): 1465-1471  
DOI: 10.1055/s-0030-1259970
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3-N,N-Bis-nucleophiles: A Facile Access to Novel Pyrimidine Derivatives

Nazar B. Maximova,b, Pavel K. Mykhailiuk*a,b, Andrei I. Kiselb, Zoia V. Voitenkob, Andrey A. Tolmacheva,b
a Enamine Ltd., Alexandra Matrosova Street 23, 01103 Kiev, Ukraine
b Department of Chemistry, Kiev National Taras Shevchenko University, Volodymyrska Street 64, 01033 Kiev, Ukraine
Fax: +380(44)2351273; e-Mail: pavel.mykhailiuk@gmail.com;
Further Information

Publication History

Received 27 January 2011
Publication Date:
24 March 2011 (online)

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Abstract

Reaction of ethyl 5-acetyl-3,4-dihydropyridine-1(2H)-carboxylate with diverse 1,3-N,N-bis-nucleophiles results in the regioselective formation of the correspondingly substituted pyrimidines in good yields.

Key words

pyrimidines - amidines - amino heterocycles - tetrahydropyridine

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