Indium-Catalyzed Synthesis
of Furans and Pyrroles via Cyclization of α-Propargyl-β-keto
Esters

Hayato Tsuji; Ken-ichi Yamagata; Yasuyuki Ueda; Eiichi Nakamura

doi:10.1055/s-0030-1259930

LETTER

Indium-Catalyzed Synthesis of Furans and Pyrroles via Cyclization of α-Propargyl-β-keto Esters

Hayato Tsuji*, Ken-ichi Yamagata, Yasuyuki Ueda, Eiichi Nakamura*
Department of Chemistry, School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Fax: +81(3)58006889; e-Mail: nakamura@chem.s.u-tokyo.ac.jp;

Abstract

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Abstract

In(OTf)₃ or In(NTf₂)₃ effectively catalyze the cycloisomerization reaction of α-propargyl-β-keto esters and their imine analogues to afford trisubstituted furans and pyrroles, respectively. Both terminal and internal alkynes take part in the reaction with good functional-group compatibility in the presence of only a small amount of the catalyst.

Key words

indium catalyst - keto ester - cyclization - furan - pyrrole

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Referenzen

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