Synlett 2011(6): 735-740  
DOI: 10.1055/s-0030-1259907
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalysed Synthesis of Stereodefined Cyclobutenes

Marco Luparia, Davide Audisio, Nuno Maulide*
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
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Further Information

Publication History

Received 6 December 2010
Publication Date:
15 March 2011 (eFirst)


The relevance of four-membered-ring substructures in organic synthesis is undeniable, and well reflected by the breadth of synthetic approaches to cyclobutanes reported in the literature. As comparatively more versatile synthetic intermediates, cyclobutenes have been the object of fewer studies. This account briefly reviews those prior reports and highlights a recent breakthrough in the ­stereoselective, atom-economical, and direct preparation of ­cyclobutenes through an intriguing combination of photochemistry and metal catalysis.