Palladium-Catalysed Synthesis of Stereodefined Cyclobutenes
15 March 2011 (eFirst)
The relevance of four-membered-ring substructures in organic synthesis is undeniable, and well reflected by the breadth of synthetic approaches to cyclobutanes reported in the literature. As comparatively more versatile synthetic intermediates, cyclobutenes have been the object of fewer studies. This account briefly reviews those prior reports and highlights a recent breakthrough in the stereoselective, atom-economical, and direct preparation of cyclobutenes through an intriguing combination of photochemistry and metal catalysis.
cyclobutenes - palladium - stereoselective synthesis - rearrangement - atom economy