Synfacts 2011(4): 0452-0452  
DOI: 10.1055/s-0030-1259742
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Dihydropyrimidinones with PEG-Supported Thiourea Dioxide

Contributor(s): Yasuhiro Uozumi, Noboru Kobayashi
S. Verma, S. L. Jain*, B. Sain
Indian Institute of Petroleum, Dehradun, India
Further Information

Publication History

Publication Date:
18 March 2011 (online)

Significance

PEG400-supported thiourea dioxide (PEG.TUD) and thiourea (PEG.TU) were prepared by the reaction of MeOPEG400-OMs and thiourea dioxide or thiourea. PEG.TUD catalyzed the three-component coupling reaction of aldehydes 1, 1,3-dicarbonyl compounds 2, and urea 3 or thiourea 4 under solvent-free conditions to give the corresponding products 5 or 6 in up to 98% yield (16 examples).