Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(4): 0395-0395
DOI: 10.1055/s-0030-1259649
DOI: 10.1055/s-0030-1259649
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Conjugated Addition of Vinylaluminums to Cyclic Enones
T. L. May, J. A. Dabrowski, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
Further Information
Publication History
Publication Date:
18 March 2011 (online)
Significance
The development of transition-metal-catalyzed enantioselective reactions allowing the formation of quaternary stereogenic centers is a challenging task. Herein, the authors report a highly enantioselective conjugated addition of Si-substituted vinylaluminum reagents to five- and six-membered cyclic β-substituted enones of type 1. A chiral bidentate NHC-copper complex has been identified to facilitate the desired transformation of 1 into 2 with good to excellent yields and enantioselectivities.