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Synfacts 2011(3): 0284-0284  
DOI: 10.1055/s-0030-1259495
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Gold-Catalyzed Hydroamination of Internal Alkynes

Contributor(s): Hisashi Yamamoto, Zhi Li
K. D. Hesp, M. Stradiotto*
Dalhousie University, Halifax, Canada
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Publication History

Publication Date:
16 February 2011 (online)

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Significance

This paper describes an efficient method to synthesize functionalized enamines. Utilizing gold catalysis, densely functionalized enamines can be obtained directly from an internal alkyne and an amine. The products are also produced in high regio- and stereoselectivities from symmetrical and unsymmetrical alkynes in most cases.