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Synfacts 2011(3): 0296-0296  
DOI: 10.1055/s-0030-1259489
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Design of a New Bisphosphine Ligand for Asymmetric Hydrogenation

Contributor(s): Hisashi Yamamoto, Patrick Brady
K. Huang, X. Zhang, T. J. Emge, G. Hou, B. Cao, X. Zhang*
Rutgers, The State University of New Jersey, Piscataway and The Pennsylvania State University, University Park, USA
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Publikationsdatum:
16. Februar 2011 (online)

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Significance

The C 1-symmetric bisphosphine ligand shown above was designed to be electron-rich and rigid, bearing a three-quandrant hindered structure. The ligand synthesis began with commercially available 1,2-cyclohexanedicarboxylic acid and featured a highly diastereoselective lithiation step, avoiding costly chiral HPLC purification.