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Synfacts 2011(3): 0315-0315
DOI: 10.1055/s-0030-1259426
DOI: 10.1055/s-0030-1259426
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Cross-Coupling of Metalated Aziridines
J. M. Nelson, E. Vedejs*
University of Michigan, Ann Arbor, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
16. Februar 2011 (online)
Significance
In this work a palladium-catalyzed cross-coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl iodides and bromides is disclosed. Only low catalyst loadings (2.5 mol%) are required and the aziridine stereochemistry is retained. The synthetic utility is shown in the synthesis of an analogue of l-furanomycin.