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Synfacts 2011(2): 0218-0218
DOI: 10.1055/s-0030-1259359
DOI: 10.1055/s-0030-1259359
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Michael Addition of β-Ketosulfones to Nitroalkenes
O. García Mancheño*, P. Tangen, R. Rohlmann, R. Fröhlich, J. Alemán*
Westfälische Wilhelms-Universität Münster, Germany and Universidad Autónoma de Madrid, Spain
Further Information
Publication History
Publication Date:
19 January 2011 (online)
Significance
The asymmetric Michael addition of β-ketosulfones to nitroalkenes catalyzed by thiourea cinchona alkaloids catalysts 1 has been reported. The authors showed that the Michael adducts could be further cyclized to enantiomerically enriched nitrones either in a stepwise or a one-pot protocol. The nitrones could also serve as substrates for TMSCN addition.