Abstract
Olefination of ester 26 which was obtained
from acid 20 and alkenol 25 using
a reduced titanium ethylidene reagent led to cyclic enol ether 28 which could be cyclized by iodospiroacetalization
to the spiroacetal core of the antifungal compound spirofungin A
(5 ).
Key words
acetal - aldol reaction - natural product - ring-closing metathesis - spirofungin
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Scheme 6
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