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Synfacts 2011(2): 0188-0188  
DOI: 10.1055/s-0030-1259265
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Hydrogenation of Fluorinated Imines

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
M.-W. Chen, Y. Duan, Q.-A. Chen, D.-S. Wang, C.-B. Yu, Y.-G. Zhou*
Dalian Institute of Chemical Physics, P. R. of China
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Publication History

Publication Date:
19 January 2011 (online)

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Significance

Chiral perfluoroalkyl amines are important building blocks in biologically active molecules. Previous attempts to hydrogenate simple fluorinated ketimines resulted in low conversion and enantioselectivity. In this work, the authors developed an efficient method to enantioselectively hydrogenate simple fluorinated ketimines with high yields and selectivities.