β-Selective Arylation of Thiophenes

Significance

In this work a general catalytic ­system for the β-selective arylation of thiophene C-H bonds with iodoarenes is reported. The ­authors ascertained in a thorough screening of substrates that the protocol proceeds with ­catalyst control and can also be applied to fused thiophene rings. Moreover, functional groups, such as esters and nitro groups, can be tolerated.