Synthesis of Tetrasubstituted Furans by Michael Addition to β-Nitroacrylates

Significance

Reported is the acidic alumina promoted Michael-type addition of α-functionalized carbonyls and β-nitroacrylates to produce tetrasubstituted furans. The equivalents of acidic alumina were examined and 1.2 g/mmol found to be optimal. This method for the synthesis of polysubstituted furans uses no solvent and benefits from modest to good yields and readily available starting materials.