Modification of a Vitamin D Analogue Using a Supported Selenium
Reagent

doi:10.1055/s-0030-1258928

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Synfacts 2010(12): 1435-1435
DOI: 10.1055/s-0030-1258928

Polymer-Supported Synthesis

Modification of a Vitamin D Analogue Using a Supported Selenium Reagent

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
W.-M. Xu*, J. He, M.-Q. Yu, G.-X. Shen
Hangzhou Normal University, P. R. of China

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Publikationsdatum:
22. November 2010 (online)

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Significance

A site-selective modification of a vitamin D analogue (deltanoid) using a polystyrene-supported selenium reagent was described. The modified vitamin D₂ attached to the selenium resin was readily converted into 9, the key intermediate of calcipotriol, via organoselenium-assisted [2,3]-sigmatropic rearrangement.