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Synfacts 2010(12): 1443-1443  
DOI: 10.1055/s-0030-1258913
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Hydrolysis of Soluble Polymer-Supported Carboxylates

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
M. Okudomi, K. Ageishi, T. Yamada, N. Chihara, T. Nakagawa, K. Mizuochi, K. Matsumoto*
Meisei University, Tokyo, Japan
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

The enzyme-mediated enantio­selective hydrolysis of water-soluble polymer-­supported caboxylates is described. Thus, mono-methoxy poly(ethylene glycol) (MPEG, average MW 5000) supported carboxylates (±)-7 were ­prepared from (±)-phenylethanol 1 in four steps. The hydrolysis of (±)-7a-g was performed with Novozym 435 in hexane-buffer (9:1) to afford the enantioenriched (R)-1 and the unreacted (S)-7a-g.