Synfacts 2010(12): 1396-1396  
DOI: 10.1055/s-0030-1258900
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Asymmetric Monohydrogenation of meso-Cyclic Imides

Contributor(s): Hisashi Yamamoto, Zhi Li
S. Takebayashi, J. M. John, S. H. Bergens*
University of Alberta, Edmonton, Canada
Further Information

Publication History

Publication Date:
22 November 2010 (online)

Significance

This paper features the first asymmetric monohydrogenation of meso-cyclic imides. A variety of cyclic imides were selectively hydrogenated on one of the two carbonyls to generate ­hydroxyl lactams in high yields and stereoselectivities.