Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(12): 1399-1399
DOI: 10.1055/s-0030-1258897
DOI: 10.1055/s-0030-1258897
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Ruthenium-Catalyzed Asymmetric Reduction of α-Keto Acids
L. Zhu, Q. Meng, W. Fan, X. Xie, Z. Zhang*
Nanjing University of Science & Technology, Shanghai Jiao Tong University and Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
The authors describe the first effective method for the asymmetric reduction of unsaturated α-keto acids, which are easily obtained by condensation of an aldehyde with pyruvic acid. These substrates are particularly challenging due to complexation of the substrate or product with the catalyst.