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Synfacts 2010(12): 1371-1371  
DOI: 10.1055/s-0030-1258889
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cooperative Ruthenium and Organocatalysis

Contributor(s): Mark Lautens, Stephen G. Newman
M. Ikeda, Y. Miyake, Y. Nishibayashi*
The University of Tokyo, Japan
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Publikationsdatum:
22. November 2010 (online)

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Significance

The combination of transition-­metal and organocatalysis allows for many remarkable reactions that would be unattainable with any single catalytic system (see Review below). Utilizing a ruthenium and a chiral amine catalyst, the authors combine aldehydes with propargylic alcohols to form propargylic alkylated products.

Review: Z. Shao, H. Zhang Chem. Soc. Rev. 2009, 38, 2745-2755.