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Synfacts 2010(12): 1401-1401
DOI: 10.1055/s-0030-1258861
DOI: 10.1055/s-0030-1258861
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Metal-Free Coupling of Aryl and Alkynyl Grignard Reagents Mediated by TEMPO
M. S. Maji, S. Murarka, A. Studer*
Westfälische Wilhelms-Universität, Münster, Germany
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
The 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) radical is used as an oxidant for the cross-coupling of aryl- and alkynylmagnesium compounds. The coupling is performed without adding any transition metals. Functional groups, such as esters, amides and cyanides, are tolerated under the reaction conditions.