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Synfacts 2010(12): 1413-1413  
DOI: 10.1055/s-0030-1258856
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

C-H Arylation of N-Heterocycles with Arylboronic Acids

Contributor(s): Paul Knochel, Thomas Kunz
I. B. Seiple, S. Su, R. A. Rodriguez, R. Gianatassio, Y. Fujiwara, A. L. Sobel, P. S. Baran*
The Scripps Research Institute, La Jolla, USA
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Publikationsdatum:
22. November 2010 (online)

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Significance

The direct coupling of arylboronic acids to electron-deficient N-heterocycles is described. The reaction is catalyzed by silver nitrate in the presence of a persulfate co-oxidant under ambient conditions. It does not require prefunctionalization of the heterocycle and shows a high functional group tolerance.