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Synfacts 2010(12): 1407-1407
DOI: 10.1055/s-0030-1258851
DOI: 10.1055/s-0030-1258851
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
ZnCl2-Enhanced Negishi Coupling of Secondary Benzyl Trifluoroacetates
H. Duan, L. Meng, D. Bao, H. Zhang, Y. Li, A. Lei*
Wuhan University, P. R. of China
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
A ZnCl2-enhanced arylation of benzyl trifluoroacetates with arylzinc reagents has been developed. The method could be applied to a broad variety of differently substituted benzyl trifluoroacetates tolerating bromo functionalities. Also sterically hindered arylzinc reagents were shown to furnish the desired coupling products in high yields.