Synfacts 2010(12): 1407-1407  
DOI: 10.1055/s-0030-1258851
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

ZnCl2-Enhanced Negishi Coupling of Secondary Benzyl Trifluoroacetates

Contributor(s): Paul Knochel, Tobias Thaler
H. Duan, L. Meng, D. Bao, H. Zhang, Y. Li, A. Lei*
Wuhan University, P. R. of China
Further Information

Publication History

Publication Date:
22 November 2010 (online)

Significance

A ZnCl2-enhanced arylation of ­benzyl trifluoroacetates with arylzinc reagents has been developed. The method could be ­applied to a broad variety of differently substituted benzyl trifluoroacetates tolerating bromo functionalities. Also sterically hindered arylzinc reagents were shown to furnish the desired coupling products in high yields.