Chemical Synthesis with Inductively Heated Copper Flow Reactors
09 July 2010 (eFirst)
Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1,3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1,2,3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular C-O coupling of 2′-bromobiphenyl-2-carboxylic acid.
click chemistry - copper - heterogeneous catalysis - microreactors - inductive heating