Synlett 2010(13): 2009-2013  
DOI: 10.1055/s-0030-1258487
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© Georg Thieme Verlag Stuttgart ˙ New York

Chemical Synthesis with Inductively Heated Copper Flow Reactors

Sascha Ceylana, Tobias Klandeb, Carla Vogtb, Carsten Friesec, Andreas Kirschning*aa Institute of Organic Chemistry and Center of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, 30167 Hannover, Germany
e-Mail: andreas.kirschning@oci.uni-hannover.de;
b Institute of Inorganic and Analytical Chemistry, Leibniz Universität Hannover, Callinstr. 1, 30167 Hannover, Germany
c PIT - Plasma Induction Technology, Lorettostr. 20, 40219 Düsseldorf, Germany
Further Information

Publication History

Received 26 April 2010
Publication Date:
09 July 2010 (eFirst)

Abstract

Inductively heated copper wire inside a flow microreactor can serve as a source for a catalytic copper species that promotes 1,3-dipolar cycloadditions of alkynes with in situ formed azides to yield 1,2,3-triazoles. The same setup was used to carry out decarboxylations of 2-alkynoic acids and for the intramolecular C-O coupling of 2′-bromobiphenyl-2-carboxylic acid.