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Synthesis 2011(1): 83-90
DOI: 10.1055/s-0030-1258345
DOI: 10.1055/s-0030-1258345
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Fluorescent Aminoxy Acids and Aminoxy Hybrid Peptides
Further Information
Received
2 September 2010
Publication Date:
30 November 2010 (online)
Publication History
Publication Date:
30 November 2010 (online)
Abstract
α-Aminoxy acid conjugates and hybrid α-aminoxy dipeptide conjugates showing blue to green fluorescence (with quantum yields 0.23-0.71) were synthesized (75-92% yield) from N-acylbenzotriazoles. 7-Methoxycoumarin derivatives were obtained (quantum yields φ 0.35-0.71) that could be suitable for peptide assays. The wavelengths of the absorption maxima (λAbs) and the fluorescence emission maxima (λEm) and the quantum yields (φ) of some coumarin-3-ylcarbonyl aminoxy acid conjugates were comparable to those of the analogous amino acid derivatives.
Key words
fluorescence - acylations - amino acids - aminoxy acids - peptides
- Supporting Information for this article is available online:
- Supporting Information
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