Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine
12 November 2010 (eFirst)
2-(Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch.
fluorine - trifluoromethyl group - amines - cyclopropyl group - sulfur tetrafluoride