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Synthesis 2010(23): 4057-4060  
DOI: 10.1055/s-0030-1258291
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Adducts of Diketene, Alcohols, and Aldehydes: Useful Building Blocks for 3,4-Dihydropyrimidinones and 1,4-Dihydropyridines

Abdolali Alizadeh*, Sadegh Rostamnia
Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran
Fax: +98(21)88006544; e-Mail: abdol_alizad@yahoo.com; e-Mail: aalizadeh@modares.ac.ir;
Further Information

Publication History

Received 20 August 2010
Publication Date:
08 October 2010 (online)

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Abstract

A novel, one-pot, solvent-free synthesis of 3,4-dihydropyrimidin-2-(1H)-one and 1,4-dihydropyridines derivatives via a four-component cyclocondensation reaction of diketene, alcohol, and aldehyde with urea or ammonium acetate is presented.

Key words

dihydropyridines - dihydropyrimidines - diketene - multicomponent reaction - neat condition

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