A New and Improved Synthesis of the Precursor of the Hypoxia Marker [^¹8F]-FMISO

Abstract

A new synthetic approach to the precursor of the hypoxia marker [^¹8F]-FMISO has been developed. Three different tosylation methods were studied for the preparation of the key intermediate. The overall yield is markedly higher than the yields reported for previous syntheses. The precursor was used to prepare [^¹8F]-FMISO and the results were comparable to those obtained when a commercial precursor was used.

Key words

[^¹8F]-FMISO - hypoxia - radiopharmaceutical - regioselective tosylation

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7

ABX Advanced Biochemical Compounds, Germany (3500 ı/1 g).

10

Aldrich Co. (317.5 ı/1 g).

11

Website of multiMag research group:
http://www.multimag.es.

12

Aldrich Co. (46.2 ı/10 g).