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Synthesis 2010(19): 3274-3281  
DOI: 10.1055/s-0030-1258189
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Expeditious Synthesis of Trifluoromethylated Heterocycles: Noncatalytic 1,3-Dipolar Cyclization of Azomethine Imines with (α-Trifluoromethyl)acrylates

Shinichi Ogawa, Takayuki Nishimine, Etsuko Tokunaga, Norio Shibata*
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan
Fax: +81(52)7357543; e-Mail: nozshiba@nitech.ac.jp;
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Publikationsverlauf

Received 7 May 2010
Publikationsdatum:
09. August 2010 (online)

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Erratum zu diesem Artikel:

Expeditious Synthesis of Trifluoromethylated Heterocycles: Noncatalytic 1,3-Dipolar Cyclization of Azomethine Imines with (α-Trifluoromethyl)acrylatesSynthesis 2010; 2010(21): 3762-3762
DOI: 10.1055/s-0030-1258288

Abstract

A convenient, simple, and expeditious procedure for the preparation of novel trifluoromethylated bicyclic pyrazolidinone systems by noncatalytic 1,3-dipolar cyclization of azomethine imines­ with tert-butyl 2-(trifluoromethyl)prop-2-enoate is presented.

Key words

bicyclic compounds - fluorine - cycloadditions - heterocycles - imines - drugs

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