A Concise Synthesis
of (2S,3S,4S)-2-(Hydroxymethyl)pyrrolidine-3,4-diol (LAB1)

Puspesh K. Upadhyay; Pradeep Kumar

doi:10.1055/s-0030-1258185

FEATUREARTICLE

A Concise Synthesis of (2S,3S,4S)-2-(Hydroxymethyl)pyrrolidine-3,4-diol (LAB1)

Puspesh K. Upadhyay, Pradeep Kumar*
Division of Organic Chemistry, National Chemical Laboratory, Pune 411 008, India
Fax: +91(2)25902629; e-Mail: pk.tripathi@ncl.res.in;

Abstract

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Abstract

The synthesis of (2S,3S,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol (LAB1) from Garner’s aldehyde is described using the Sharpless asymmetric dihydroxylation as the key step.

Key words

Garner’s aldehyde - Wittig reaction - diastereoselectivity - alkaloid - azasugars - pyrrolidine

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Referenzen

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