Synthesis 2010(17): 2997-3003  
DOI: 10.1055/s-0030-1258182
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Photoaffinity-Labeled Peptoids and Depsipeptides by Multicomponent Reactions

Michael Henzea, Oliver Kreyea, Sebastian Braucha, Christoph Nitschea, Kai Naumannc, Ludger A. Wessjohanna,b, Bernhard Westermann*a,b
a Leibniz-Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, 06120 Halle (Saale), Germany
Fax: +49(34)555821309; e-Mail: bwesterm@ipb-halle.de;
b Martin-Luther-University, Institute of Organic Chemistry, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany
c Leibniz-Institute of Plant Biochemistry, Department of Stress and Developmental Biology, Weinberg 3, 06120 Halle (Saale), Germany
Further Information

Publication History

Received 18 February 2010
Publication Date:
16 July 2010 (online)

Abstract

Photoaffinity tags can be incorporated easily into peptoids and congeners by the Ugi and Passerini multicomponent reactions. Products related to photo-methionine and photo-leucine can be accomplished by diazirine-containing building blocks. The same protocols can be used to synthesize derivatives with benzophenone photo cross-linkers.

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