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Synthesis 2010(18): 3083-3086  
DOI: 10.1055/s-0030-1258163
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple and Convenient Per-O-acylation of Cyclodextrins Catalyzed by Molecular Iodine

Yasuhiro Ide, Yuji Hori, Soichi Kobayashi, Md. Delwar Hossain, Tsugio Kitamura*
Department of Chemistry and Applied Chemistry, Graduate School of Science and Engineering, Saga University, Honjo-machi, Saga 840-8502, Japan
Fax: +81(952)288550; e-Mail: kitamura@cc.saga-u.ac.jp;
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Publication History

Received 2 April 2010
Publication Date:
07 July 2010 (online)

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Abstract

Per-O-acylated cyclodextrins with different alkyl chains were prepared in good to high yields by iodine-catalyzed acylation of all hydroxy groups of cyclodextrins with carboxylic anhydrides under solvent-free conditions.

Key words

cyclodextrins - iodine catalyst - acylation - solvent-free

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This compound is commercially available.