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Synthesis 2010(16): 2794-2798  
DOI: 10.1055/s-0030-1258146
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed One-Pot Synthesis of Substituted Benzimidazo[1,2-a]quinolines

Bing-Wei Zhou, Jian-Rong Gao, Dong Jiang, Jian-Hong Jia, Zhen-Ping Yang, Hong-Wei Jin*
College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
Fax: +86(571)88320415; e-Mail: jhwei828@zjut.edu.cn;
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Publication History

Received 19 March 2010
Publication Date:
01 July 2010 (online)

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Abstract

A one-pot procedure for the synthesis of substituted benzimidazo[1,2-a]quinolines from the corresponding benzimidazoles and 2-bromobenzaldehydes has been developed. The titled products were prepared through Knoevenagel condensation and copper-catalyzed­ intramolecular Ullmann-type coupling in moderate to good yields.

Key words

Knoevenagel condensation - copper catalyst - Ullmann coupling - quinoline synthesis - cascade process

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