Synthesis of Enantiopure Quaternary
Prolines by a Metathesis Process of 2,5-Ethenoproline
Derivatives

Javier Carreras; Alberto Avenoza; Jesús H. Busto; Jesús M. Peregrina

doi:10.1055/s-0030-1257907

PAPER

Synthesis of Enantiopure Quaternary Prolines by a Metathesis Process of 2,5-Ethenoproline Derivatives

Javier Carreras, Alberto Avenoza*, Jesús H. Busto*, Jesús M. Peregrina
Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, UA-CSIC, 26006 Logroño, Spain
Fax: +34(941)299621; e-Mail: alberto.avenoza@unirioja.es; e-Mail: hector.busto@unirioja.es ;

Abstract

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Abstract

A novel azabicyclic amino acid was synthesized in both enantiopure forms. The ring-opening metathesis of methyl N-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene-1-carboxylates was used as a method for accessing a new family of enantiopure proline analogues.

Key words

metathesis - bicyclic compounds - heterocycles - amino acids - stereoselective synthesis

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References

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