Endoskopie heute 2010; 23(2): 108-112
DOI: 10.1055/s-0030-1247442
Originalarbeit

© Georg Thieme Verlag KG Stuttgart ˙ New York

Kapselendoskopie: Vorbereitung und Prokinetika

Capsule Endoscopy: Preparation and ProcineticsD. Hartmann1 , R. Jakobs2
  • 1Medizinische Klinik C, Klinikum der Stadt Ludwigshafen gGmbH
  • 2Akademisches Lehrkrankenhaus der Johannes Gutenberg-Universität Mainz
Further Information

Publication History

Publication Date:
20 July 2010 (online)

Zusammenfassung

Durch die Einführung der Kapselendoskopie wurde die Untersuchung des Dünndarms revolutioniert, insbesondere die Diagnostik einer mittleren gastrointestinalen Blutung. Die Diagnostik mittels der Kapselendoskopie kann jedoch eingeschränkt sein durch das Vorhandensein von Stuhlresten oder Luftblasen. Im Gegensatz zur Hersteller­empfehlung verbessert die Vorbereitung mittels Darmlavage die Sicht auf die Mukosa und erhöht hierdurch die diagnostische Ausbeute. Ein weiteres Problem ist die inkomplette Untersuchung des Dünndarms durch eine verzögerte Magen- und / oder Dünndarmtransitzeit. In mehreren Studien konnte kein eindeutiger Vorteil für den zusätzlichen Einsatz eines Prokinetikums gezeigt werden.

Abstract

The introduction of video capsule endoscopy has revolutionized the diagnosis of small bowel dis­eases, particulary the analysis of obscure gastrointestinal bleeding. Although capsule endoscopy has been shown to be superior to alternative techniques for diagnosis small bowel lesions, its diagnostic yield can be limited by the presence of dark or opaque fluid or air bubbles, which can hamper or prevent diagnosis by causing incomplete visualization of the intestinal mucosa. Current evidence indicates that bowel preparation with purgative agents increases the diagnostic yield of the procedure by improving small bowel mucosal visu­alization compared with a clear liquid diet or overnight fast. Furthermore, slow gastric emptying or small bowel transit can prevent the capsule from reaching the ileo-cecal valve within the battery life of approximately 8 hours. At this time, it is unclear, if procinetic drugs could improve the proportion of cases in which the colon is reached during the recording time.

Literatur

  • 1 Rondotti E, Soncini M, Girelli C et al. Small bowel capsule endoscopy in clinical practice: a multicenter 7-year survey.  Eur J Gastroenterol Hepatol. 2010;  ,  epub
  • 2 Velayos B, Herreros de Trejada A, Fernandez L et al. Upper gastrointestinal findings detected by capsule endoscopy in obscure gastrointestinal bleeding.  Rev esp nferm Dig. 2009;  101 11-19
  • 3 Peter S, Heuss L T, Beglinger C et al. Capsule endoscopy of the upper gastrointestinal tract – the need for a second endoscopy.  Digestion. 2005;  72 242-247
  • 4 Kitiyakara T, Selby W. Non-small-bowel lesions detected by capsule endoscopy in patients with obscure GI bleeding.  Gastrointest Endosc. 2005;  62 234-238
  • 5 Delvaux M, Fassler I, Gay G. Clinical usefullness of the endoscopic video capsule as the initial intestinal investigation in patients with obscure digestive bleeding: validation of a diagnostic strategy based on the ­patient outcome after 12 months.  Endoscopy. 2004;  36 1067-1073
  • 6 Carey E J, Leighton J A, Heigh R I et al. A single-center experience of 260 consecutive patients undergoing capsule endoscopy for obscure gastrointestinal bleeding.  Am J Gastroenterol. 2007;  102 89-95
  • 7 Lara L F, Bloomfeld R S, Pineau B C. The rate of lesions found within reach of esophagogastroduodenosopy during push enteroscopy depends on the type of obscure gastrointestinal bleeding.  Endoscopy. 2004;  36 745-750
  • 8 May A, Wardak A, Nachbar L et al. Influence of patient selection on the outcome of capsule endoscopy in patients with chronic gastrointestinal bleeding.  J Clin Gastroenterol. 2005;  39 684-688
  • 9 Ell C, Remke S, May A et al. The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding.  Endoscopy. 2002;  34 685-689
  • 10 Sidhu R, Sanders D S, Kapur K et al. Factors predicting the dagnostic yield and intervention in obscure gastrointestinal bleeding investigated using capsule endoscopy.  J Gastrointest Liver Dis. 2009;  18 273-278
  • 11 Zhang B L, Fang Y H, Chen C X et al. Single-center rxperience of 309 consecutive patients with obscure gastrointestinal bleeding.  World J Gastroenterol. 2009;  15 5740-5745
  • 12 Cheifetz A S, Kornbluth A A, Legnani P et al. The risk of retention of the capsule endoscope in patients with known or suspected Crohn’s disease.  Am J Gastroenterol. 2006;  101 2218-2222
  • 13 Albert J G, Martiny F, Krummenerl A et al. Diagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis.  Gut. 2005;  54 1721-1727
  • 14 Chong A KH, Taylor A, Miller A et al. Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn’s disease.  Gastrointest Endosc. 2005;  61 255-261
  • 15 Voderholzer W A, Beinhoelzl J, Rogalla P et al. Small bowel involvement in Crohn’s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis.  Gut. 2005;  54 369-373
  • 16 Liao Z, Gao R, Xu C et al. Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review.  Gastrointest Endosc. 2010;  71 280-286
  • 17 Li F, Gurudu S R, De Petris G et al. Retention of the capsule endoscope: a single-center experience of 1000 capsule endoscopy procedures.  Gastrointest Endosc. 2008;  68 174-180
  • 18 Postgate A J, Burling D, Gupta A et al. Safety, reliability and limitations of the Given patency capsule in patients at risk of capsule retention: A 3-year technical review.  Dig Dis Sci. 2008;  53 2732-2738
  • 19 Signorelli C, Rondonotti E, Villa F et al. Use of the Given Patency System for the screening of patients at high risk for capsule retention.  Dig Liver Dis. 2006;  38 326-330
  • 20 Spada C, Riccioni M E, Costamagna G. The new, dissolving patency capsule: a safe and effective tool to avoid the complication of retained ­video capsules.  J Clin Gastroenterol. 2008;  42 761-762
  • 21 Herrerias J M, Leighton J A, Costamagna G et al. Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy.  Gastrointest Endosc. 2008;  67 902-909
  • 22 Bandorski D, Irnich W, Brück M et al. Capsule endoscopy and cardiac pacemakers: investigation for possible interference.  Endoscopy. 2008;  40 36-39
  • 23 Bandorski D, Irnich W, Brück M et al. Do endoscopy capsules interfere with implantable cardioverter-defibrillators?.  Endoscopy. 2009;  41 457-461
  • 24 Bandorski D, Diehl K L, Jaspersen D. Capsule endoscopy in patients with cardiac pacemakers: current situation in Germany.  Z Gastroenterol. 2005;  43 715-718
  • 25 Leighton J A, Srivathsan K, Carey E J et al. Safety of wireless capsule endos­copy in patients with implantable cardiac defibrillators.  Am J Gastroenterol. 2005;  100 1728-1731
  • 26 Leighton J A, Sharma V K, Srivathsan K et al. Safety of capsule endoscopy in patients with pacemakers.  Gastrointest Endosc. 2004;  59 567-569
  • 27 Dirks M H, Costea F, Seidman E G. Successful videocapsule endoscopy in patients with an abdominal cardiac pacemaker.  Endoscopy. 2008;  40 73-75
  • 28 Dubner S, Dubner Y, Rubio H et al. Electromagnetic interference from wireless video-capsule endoscopy on implantable cardioverter-defibrillators.  Pacing Clin Electrophysiol. 2007;  30 472-475
  • 29 Holden J P, Dureja P, Pfau P R et al. Endoscopic placement of the small-bowel video capsule by using a capsule endoscope delivery device.  Gastrointest Endosc. 2007;  65 842-847
  • 30 Carey E J, Heigh R I, Fleischer D E. Endoscopic capsule endoscope delivery for patients with dysphagia, anatomical abnormalities, or gastropa­re­sis.  Gastrointest Endosc. 2004;  59 423-426
  • 31 Albert J, Göbel C M, Lesske J et al. Simethicone for small bowel preparation for capsule endoscopy: a systematic, single-blinded, controlled study.  Gastrointest Endosc. 2004;  59 487-491
  • 32 Ge Z Z, Chen H Y, Gao Y J et al. The role of simeticone in small-bowel prep­aration for capsule endoscopy.  Endoscopy. 2006;  38 836-840
  • 33 Wei W, Ge Z Z, Lu H et al. Purgative bowel cleansing combined with simethicone improves capsule endoscopy imaging.  Am J Gastroenterol. 2008;  103 77-82
  • 34 Fang Y H, Chen C X, Zhang B L. Effect of small bowel preparation with ­simethicone on capsule endoscopy.  J Zhejiang Univ Sci B. 2009;  10 46-51
  • 35 Spada C, Riccioni M E, Familiari P et al. Polyethylene glycol plus simethicone in small-bowel preparation for capsule endoscopy.  Dig Liver Dis. 2009;  ,  [Epub ahead of print]
  • 36 Esaki M, Matsumoto T, Kudo T et al. Bowel preparations for capsule endoscopy: a comparison between simethicone and magnesium citrate.  Gastrointest Endosc. 2009;  69 94-101
  • 37 Rokkas T, Papaxoinis K, Triantafyllou K et al. Does purgative preparation influence the diagnostic yield of small bowel video capsule endoscopy?: A meta-analysis.  Am J Gastroenterol. 2009;  104 219-227
  • 38 Viazis N, Sgouros S, Papaxoinis K et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study.  Gastrointest Endosc. 2004;  60 534-538
  • 39 Ben-Soussan E, Savoye G, Antonietti M et al. Is a 2-liter PEG preparation useful before capsule endoscopy?.  J Clin Gastroenterol. 2005;  39 381-384
  • 40 van Tuyl S A, den Ouden H, Stolk M F et al. Optimal preparation for video capsule endoscopy: a prospective, randomized, single-blind study.  ­Endoscopy. 2007;  39 1037-1040
  • 41 Wi J, Moon J, Kim Y et al. A prospective randomized multicenter study of preparation for capsule endoscopy.  Gastrointest Endoscopy. 2006;  63 Supp S , AB M1310, AB 168
  • 42 Lapalus M G, Ben-Soussan E, Saurin J C. Capsule endoscopy and bowel preparation with oral sodium phosphate: a prospective randomized controlled trial.  Gastrointest Endosc. 2008;  67 1091-1096
  • 43 Niv Y, Niv G, Wiser K et al. Capsule endoscopy – comparison of two strategies of bowel preparation.  Aliment Pharmacol Ther. 2005;  22 957-962
  • 44 Niv Y, Niv G. Capsule endoscopy: role of bowel preparation in successful visualization.  Scand J Gastroenterol. 2004;  39 1005-1009
  • 45 Pons V, Gonzalez B, Gonzalez C et al. Evaluation of different bowel prep­arations for the study with capsule endoscopy: a prospective, randomized, controlled study.  Gastrointest Endosc. 2006;  63 AB161
  • 46 Dai N, Gubler C, Hengstler P et al. Improved capsule endoscopy after bowel preparation.  Gastrointest Endosc. 2005;  61 28-31
  • 47 Kalantzis C, Triantafyllou K, Papadopoulos A A et al. Effect of three bowel preparations on video-capsule endoscopy gastric and small-bowel transit time and completeness of the examination.  Scand J Gastro­enterol. 2007;  42 1120-1126
  • 48 Kantianis A, Karagiannis S, Liatsos C et al. Comparison of two schemes of small bowel preparation for capsule endoscopy with polyethylene glycol: a prospective, randomized single-blind study.  Eur J Gastro­enterol Hepatol. 2009;  21 1140-1144
  • 49 Leung W K, Chan F K, Fung S S et al. Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.  World J Gastro­enterol. 2005;  11 4865-4868
  • 50 Fireman Z, Paz D, Kopelman Y. Capsule endoscopy: improving transit time and image view.  World J Gastroenterol. 2005;  11 5863-5866
  • 51 Caddy G R, Moran L, Chong A K et al. The effect of erythromycin on video capsule endoscopy intestinal-transit time.  Gastrointest Endosc. 2006;  63 262-266
  • 52 Niv E, Bonger I, Barkay O et al. Effect of erythromycin on image quality and transit time of capsule endoscopy: a two-center study.  World J Gastroenterol. 2008;  14 2561-2565
  • 53 Hooks 3rd  S B, Rutland T J, Di Palma J A. Lubiprostone neither decreases gastric and small-bowel transit time nor improves visualization of small bowel for capsule endoscopy: a double-blind, placebo-controlled study.  Gastrointest Endosc. 2009;  70 942-946
  • 54 Selby W. Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide.  Gastrointest Endosc. 2005;  61 80-85
  • 55 Almeida N, Figueiredo P, Freire P et al. The effect of metoclopramide in capsule enteroscopy.  Dig Dis Sci. 2010;  55 153-157
  • 56 Apostolopoulos P, Kalantzis C, Gralnek I M et al. Clinical trial: effectiveness of chewing-gum in accelerating capsule endoscopy transit time – a prospective randomized, controlled pilot study.  . 2008;  28 405-411

Priv. Doz. Dr. D. Hartmann

Medizinische Klinik C · Klinikum der Stadt Ludwigshafen

Bremserstr. 79

67063 Ludwigshafen

Phone: 06 21 / 5 03 41 61

Email: hartmand@klilu.de

    >