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Synfacts 2010(7): 0828-0828
DOI: 10.1055/s-0029-1220115
DOI: 10.1055/s-0029-1220115
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Chiral Phosphoric Acid Catalyzed Intramolecular Oxo-Michael Reactions
Q. Gu, Z.-Q. Rong, C. Zheng, S.-L. You*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
This work describes the desymmetrization of cyclohexadienones utilizing a chiral phosphoric acid 1 catalyzed intramolecular oxo-Michael addition. In the presence of 1 different cyclohexadienones cyclized readily to give the corresponding products in high yields and enantioselectivities. The versatility of this reaction was demonstrated in the asymmetric synthesis of three cleroindicin natural products.