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Synfacts 2010(7): 0845-0845  
DOI: 10.1055/s-0029-1220095
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Henry Reaction with an M-HMMS-Supported Copper Complex

Contributor(s): Yasuhiro Uozumi, Noboru Kobayashi
J.-M. Lee, J. Kim, Y. Shin, C.-E. Yeom, J. E. Lee, T. Hyeon*, B. M. Kim*
Seoul National University, South Korea
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

The chiral bis(oxazoline)-copper complex 3 immobilized on magnetically separable mesocellular mesopourus silica (M-HMMS silica) was prepared by 1,3-dipolar cycloaddition of 2 with 1 followed by treatment with Cu(OAc)2. The immobilized copper complex 3 catalyzed the asymmetric Henry reaction of benzaldehydes with nitromethane to give the corresponding products in up to 97% yield and 84% ee.