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Synfacts 2010(7): 0780-0780
DOI: 10.1055/s-0029-1220079
DOI: 10.1055/s-0029-1220079
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Zinc-Catalyzed Phospha-Michael Reaction of Phosphine Oxides
D. Zhao, L. Mao, Y. Wang, D. Yang, Q. Zhang, R. Wang*
Lanzhou University, P. R. of China
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
The synthesis of chiral phosphine containing motifs has become a popular endeavor in asymmetric synthesis owing to their interesting biological properties and applications as chiral synthons and ligands. Phosphines and alkyl phosphites can be used as nucleophiles in 1,2- and 1,4-additions, but examples of phosphine oxides are less common. Herein, the authors describe an asymmetric application of phosphine oxides as nucleophiles in a Michael-type addition.