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Synfacts 2010(7): 0777-0777  
DOI: 10.1055/s-0029-1220064
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Cyclophanes

Contributor(s): Timothy M. Swager, Jose M. Lobez
K. Kanda, K. Endo, T. Shibata*
Waseda University, Tokyo, Japan
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Publikationsverlauf

Publikationsdatum:
22. Juni 2010 (online)

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Significance

An asymmetric synthesis of chiral cyclophanes is achieved via ortho-lithiation in the presence of catalytic or stoichiometric amounts of a chiral ligand, followed by quenching with an electrophile. Chiral cyclophanes 2 and 3 are obtained this way with good to excellent enantiomeric excess.