Bromomagnesium Thiolate Catalyzed Tishchenko Reaction

L. Cronin; F. Manoni; C. J. O’Connor; S. J. Connon

doi:10.1055/s-0029-1220044

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Synfacts 2010(7): 0817-0817
DOI: 10.1055/s-0029-1220044

Metal-Mediated Synthesis

Bromomagnesium Thiolate Catalyzed Tishchenko Reaction

Contributor(s): Paul Knochel, Tobias Thaler
L. Cronin, F. Manoni, C. J. O’Connor, S. J. Connon*
The University of Dublin, Ireland

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Publication History

Publication Date:
22 June 2010 (online)

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Significance

A biomimetic bromomagnesium thiolate catalyzed Tishchenko-Claisen reaction was developed. Tuning of the thiolate catalyst even allows for the intermolecular coupling of aldehydes with trifluoromethylketones.