Platinum- and Gold-Catalyzed Cyclizations of Alkynes

M. Gruit; D. Michalik; K. Krüger; A. Spannenberg; A. Tillack; A. Pews-Davtyan; M. Beller

doi:10.1055/s-0029-1220042

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Synfacts 2010(7): 0814-0814
DOI: 10.1055/s-0029-1220042

Metal-Mediated Synthesis

Platinum- and Gold-Catalyzed Cyclizations of Alkynes

Contributor(s): Paul Knochel, Andreas J. Wagner
M. Gruit, D. Michalik, K. Krüger, A. Spannenberg, A. Tillack, A. Pews-Davtyan, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany

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Publication History

Publication Date:
22 June 2010 (online)

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Significance

A novel synthesis of potentially bioactive pyrroloazepinones is disclosed based on the catalytic intramolecular cyclization of alkyne-substituted 1H-pyrrole-2-carboxylic acid amides. These substrates readily form pyrrolo[3,2-c]azepin-ones in the presence of either H₂PtCl₆ or AuCl₃.