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Synthesis 2010(10): 1609-1612  
DOI: 10.1055/s-0029-1219762
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple and Efficient Method for the Three-Component Synthesis of Homoallylic Amines Catalyzed by Indium Triflate

A. Venkat Narsaiah*, J. Kranthi Kumar, P. Narsimha
Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India
Fax: +91(40)27160387; e-Mail: vnakkirala2001@yahoo.com;
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Publication History

Received 8 January 2010
Publication Date:
06 April 2010 (online)

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Abstract

Indium triflate catalyzes efficiently the one-pot three-component condensation of aldehydes, amines, and allyltributylstannane to afford the corresponding products of homoallylic amines in excellent yields at room temperature. All reactions were carried out using the catalyst in 10 mol%. This methodology was successfully applied to a variety of aldehydes and amines.

Key words

aldehydes - amines - allyltributylstannane - indium triflate - homoallylic amines

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